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Invitrogen
TRIM6 Polyclonal Antibody
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Product Details
PA5-63865
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TRIM6. Recombinant protein control fragment (Product #RP-100872).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VQSYWVDVTL NPHTANLNLV LAKNRRQVRF VGAKVSGPSC LEKHYDCSVL GSQHFS
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.
Target Information
TRIM6 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6; tripartite motif-containing 6; Tripartite motif-containing protein 6
Gene Aliases: RNF89; TRIM6
UniProt ID: (Human) Q9C030
Entrez Gene ID: (Human) 117854
protein polyubiquitination
positive regulation of defense response to virus by host
positive regulation of cytokine secretion involved in immune response
positive regulation of gene expression
negative regulation of gene expression
positive regulation of peptidyl-threonine phosphorylation
free ubiquitin chain polymerization
response to lipopolysaccharide
positive regulation of peptidyl-serine phosphorylation
cellular response to interferon-beta
negative regulation of viral genome replication
negative regulation of transcription, DNA-templated
positive regulation of type I interferon-mediated signaling pathway
protein trimerization
cellular response to virus
regulation of NIK/NF-kappaB signaling
positive regulation of transcription regulatory region DNA binding
negative regulation of stem cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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