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Invitrogen
CHMP1B Polyclonal Antibody
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Product Details
PA5-63997
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHMP1B. Recombinant protein control fragment (Product #RP-103426).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QNQVDMLLQE MADEAGLDLN MELPQGQTGS VGTSVASAEQ DELSQRLARL RDQV
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 96%.
Target Information
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 ).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charged multivesicular body protein 1b; CHMP1.5; CHMP1b; chromatin modifying protein 1B; Chromatin-modifying protein 1b; similar to CHMP1; unnamed protein product; vacuolar protein sorting 46-2; Vacuolar protein sorting-associated protein 46-2; VPS46 homolog B; Vps46-2
Gene Aliases: C10orf2; C18-ORF2; C18orf2; CHMP1.5; CHMP1B; hVps46-2; Vps46-2; Vps46B
UniProt ID: (Human) Q7LBR1
Entrez Gene ID: (Human) 57132
plasma membrane repair
autophagy
nucleus organization
vacuolar transport
mitotic metaphase plate congression
regulation of centrosome duplication
protein transport
nuclear envelope reassembly
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
establishment of protein localization
late endosome to vacuole transport
viral budding from plasma membrane
cell division
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
ESCRT III complex disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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