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Invitrogen
CHMP4A Polyclonal Antibody
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Product Details
PA5-64372
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHMP4A. Recombinant protein control fragment (Product #RP-104057).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: THLPAGPAPK VDEDEEALKQ LAEWVS
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 42%.
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charged multivesicular body protein 4a; CHMP4a; chromatin modifying protein 4A; Chromatin-modifying protein 4a; hSnf-1; hVps32-1; similar to yeast Snf7p; SNF7 homolog associated with Alix-2; Snf7 homologue associated with Alix 2; SNF7-1; Vacuolar protein sorting-associated protein 32-1; Vps32-1
Gene Aliases: C14orf123; CDA04; CHMP4; CHMP4A; CHMP4B; hSnf7-1; HSPC134; SHAX2; SNF7; SNF7-1; VPS32-1; VPS32A
UniProt ID: (Human) Q9BY43
Entrez Gene ID: (Human) 29082
plasma membrane repair
posttranslational protein targeting to membrane
membrane budding
autophagy
nucleus organization
vacuolar transport
mitotic metaphase plate congression
membrane invagination
protein transport
macroautophagy
nuclear envelope reassembly
late endosome to vacuole transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding from plasma membrane
neurological system process
protein polymerization
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
membrane tubulation
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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