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Invitrogen
KCC2 Polyclonal Antibody
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Product Details
PA5-64474
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCC2. Recombinant protein control fragment (Product #RP-104242).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ILKQMHLTKN EREREIQSIT DESRGSIRRK NPANTRLRLN VPEETAGDSE EKPEEEVQLI HDQSAPSC
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 81%.
Target Information
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Electroneutral potassium-chloride cotransporter 2; erythroid K-Cl cotransporter 2; hKCC2; K-Cl cotransporter 2; KCC 2; Neuronal K-Cl cotransporter; S12A5; solute carrier family 12 (potassium/chloride transporter), member 5; Solute carrier family 12 member 5; unnamed protein product
Gene Aliases: DEE34; EIEE34; EIG14; hKCC2; KCC2; KIAA1176; SLC12A5
UniProt ID: (Human) Q9H2X9
Entrez Gene ID: (Human) 57468
ion transport
potassium ion transport
chloride transport
cell volume homeostasis
hypotonic response
chemical synaptic transmission
learning
response to xenobiotic stimulus
cellular chloride ion homeostasis
developmental process
multicellular organism growth
thermosensory behavior
intracellular pH reduction
chloride ion homeostasis
potassium ion homeostasis
transmembrane transport
dendritic spine development
potassium ion transmembrane transport
ammonium transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynapse assembly
chloride transmembrane transport
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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