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Invitrogen
FBXO4 Polyclonal Antibody
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Product Details
PA5-64893
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human FBXO4. Recombinant protein control fragment (Product #RP-105693).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HEWQDEFSHIM AMTDPAFGSS GRPLLVLSCI SQGDVKRMPC FYLAHELHLN LLNHPWLVQD TEAETLTGFL NGIEWILEEV ESK
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 93%.
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box only protein 4; F-box protein Fbx4; unnamed protein product
Gene Aliases: FBX4; FBXO4
UniProt ID: (Human) Q9UKT5
Entrez Gene ID: (Human) 26272
protein polyubiquitination
telomere maintenance
cytoplasmic translational initiation
ubiquitin-dependent protein catabolic process
regulation of macromolecule biosynthetic process
posttranscriptional regulation of gene expression
protein ubiquitination
cellular homeostasis
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
regulation of protein stability
protein destabilization
positive regulation of telomere maintenance via telomerase
common myeloid progenitor cell proliferation
positive regulation of translation
negative regulation of fibroblast proliferation
cellular response to ionizing radiation
cellular senescence
membraneless organelle assembly
negative regulation of protein localization to nucleus
positive regulation of protein polyubiquitination
regulation of DNA damage checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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