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Invitrogen
DDRGK1 Polyclonal Antibody
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Product Details
PA5-64951
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment of Human DDRGK1 (Product #RP-90580).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ASAGQEPLHNE ELAGAGRVAQ PGPLEPEEPR AGGRPRRRRD LGSRLQAQRR AQRVAWAEAD ENEEEAVIL
Highest antigen sequence identity to the following orthologs - mouse 68%, rat 70%.
Target Information
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. May also play a role in the cellular response to endoplasmic reticulum stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dashurin; DDRGK domain-containing protein 1; UFM1-binding and PCI domain-containing protein 1; UFM1-binding protein 1 containing a PCI domain
Gene Aliases: C20orf116; DDRGK1; dJ1187M17.3; SEMDSH; UFBP1
UniProt ID: (Human) Q96HY6
Entrez Gene ID: (Human) 65992
blood circulation
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
ribosome disassembly
regulation of intracellular estrogen receptor signaling pathway
response to endoplasmic reticulum stress
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
cartilage development
reticulophagy
protein localization to endoplasmic reticulum
protein ufmylation
rescue of stalled ribosome
positive regulation of reticulophagy
positive regulation of plasma cell differentiation
positive regulation of proteasomal protein catabolic process
positive regulation of cell cycle G1/S phase transition
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of I-kappaB phosphorylation
negative regulation of IRE1-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response
positive regulation of protein localization to endoplasmic reticulum
protein K69-linked ufmylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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