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Invitrogen
KCNH1 Polyclonal Antibody
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Product Details
PA5-64954
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human KCNH1. Recombinant protein control fragment (Product #RP-91156).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DSCDSGITKSD LRLDNVGEAR SPQDRSPILA EVKHSFYPIP EQTLQATVLE VRHELKEDIK ALNAKMTNIE KQLSEILRIL TSRRSSQSPQ ELFEISRPQS PES
Highest antigen sequence identity to the following orthologs - mouse 91%, rat 92%.
Target Information
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH1 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH1 is activated at the onset of myoblast differentiation. KCNH1 is highly expressed in brain and in myoblasts. Overexpression of KCNH1 may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of KCNH1 results in two transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAG channel 1; ether-a-go-go 1; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; Kv10.1 E65; Kv10.1 E70; potassium channel, voltage gated eag related subfamily H, member 1; Potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; unnamed protein product; Voltage-gated delayed rectifier potassium channel KCNH1; Voltage-gated potassium channel subunit Kv10.1
Gene Aliases: EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1; KCNH1; Kv10.1; TMBTS; ZLS1
UniProt ID: (Human) O95259
Entrez Gene ID: (Human) 3756
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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