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Invitrogen
MAD2L2 Polyclonal Antibody
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Product Details
PA5-64994
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human MAD2L2. Recombinant protein control fragment (Product #RP-105755).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLLSHVEQLLR AFILKISVCD AVLDHNPPGC TFTVLVHTRE AATRNMEKIQ VIKDFPWILA DEQDVH
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; Mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; REV7 homolog; RP3-330O12.4
Gene Aliases: MAD2B; MAD2L2; POLZ2; REV7
UniProt ID: (Human) Q9UI95
Entrez Gene ID: (Human) 10459
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
double-strand break repair
transcription, DNA-templated
actin filament organization
mitotic nuclear division
mitotic spindle assembly checkpoint
negative regulation of epithelial to mesenchymal transition
negative regulation of transcription by competitive promoter binding
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein catabolic process
error-prone translesion synthesis
DNA damage response, signal transduction resulting in transcription
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
cell division
negative regulation of canonical Wnt signaling pathway
negative regulation of ubiquitin protein ligase activity
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of transcription regulatory region DNA binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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