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Invitrogen
ATOH8 Polyclonal Antibody
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Product Details
PA5-65024
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human ATOH8. Recombinant protein control fragment (Product #RP-105790).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKHIPVLEDGP WKTVCVKELN GLKKLKRKGK EPARRANGYK TFRLDLEAPE PRAVATNGLR DRTHRLQPVP VPVPVPVPYG APHR
Highest antigen sequence identity to the following orthologs - mouse 73%, rat 72%.
Target Information
Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: atonal homolog 6; atonal homolog 8; atonal homolog bHLH transcription factor 8; basic helix loop helix transcription factor 6; bHLHa21; Class A basic helix-loop-helix protein 21; Hath6; Helix-loop-helix protein hATH-6; Protein atonal homolog 8; Transcription factor ATOH8; unnamed protein product
Gene Aliases: ATH6; ATOH8; BHLHA21; HATH6
UniProt ID: (Human) Q96SQ7
Entrez Gene ID: (Human) 84913
formation of primary germ layer
negative regulation of endothelial cell proliferation
nervous system development
anatomical structure morphogenesis
positive regulation of endothelial cell migration
negative regulation of gene expression
cell differentiation
tube formation
positive regulation of endothelial cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
myoblast proliferation
positive regulation of SMAD protein import into nucleus
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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