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Invitrogen
Alpha A Crystallin Polyclonal Antibody
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Product Details
PA5-65192
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CRYAA. Recombinant protein control fragment (Product #RP-105610).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KHNERQDDHGY ISREFHRRYR LPSNVDQSAL SCSLSADGML TFCGPKIQTG LDATHAERAI PVSREEKPTS A
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acry 1; Alpha-crystallin A chain; CRYA 1; CRYAA; Crystallin Alpha 1; crystallin, alpha-1; Heat shock protein beta-4; Heat shock protein family B member 4; HSPB 4; HspB4; human alphaA-crystallin (CRYA1)
Gene Aliases: CRYA1; CRYAA; CRYAA2; CTRCT9; HSPB4
UniProt ID: (Human) P02489
Entrez Gene ID: (Human) 1409, (Human) 102724652
response to hypoxia
lens development in camera-type eye
lens morphogenesis in camera-type eye
apoptotic process
mitochondrion organization
actin filament organization
microtubule-based process
tubulin complex assembly
visual perception
response to heat
negative regulation of gene expression
positive regulation of cell growth
negative regulation of intracellular transport
protein refolding
response to hydrogen peroxide
camera-type eye development
negative regulation of apoptotic process
embryonic camera-type eye morphogenesis
protein stabilization
apoptotic process involved in morphogenesis
response to UV-A
lens fiber cell morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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