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Invitrogen
EDA Polyclonal Antibody
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Product Details
PA5-65198
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human EDA. Recombinant protein control fragment (Product #RP-105941).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELRSELRRERG AESRLGGSGT PGTSGTLSSL GGLDPDSPIT SHLGQPSPKQ QPLEPGEAAL HS
Highest antigen sequence identity to the following orthologs - mouse 78%, rat 78%.
Target Information
EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. This protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in the gene for EDA are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ectodermal dysplasia protein; Ectodysplasin; Ectodysplasin-A; EDA 1; EDA protein; oligodontia 1; tumor necrosis factor ligand 7C; X-linked anhidroitic ectodermal dysplasia protein
Gene Aliases: ECTD1; ED1; ED1-A1; ED1-A2; EDA; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; STHAGX1; TNLG7C; XHED; XLHED
UniProt ID: (Human) Q92838
Entrez Gene ID: (Human) 1896
immune response
cell-matrix adhesion
gene expression
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
pigmentation
positive regulation of NF-kappaB transcription factor activity
salivary gland cavitation
hair follicle placode formation
trachea gland development
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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