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Invitrogen
PKC lambda/iota Polyclonal Antibody
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Product Details
PA5-65216
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PKC lambda/iota. Recombinant protein control fragment (Product #RP-105954).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STMSHTVAGGG SGDHSHQVRV KAYYRGDIMI THFEPSISFE GLCNEVRDMC SFDNEQLFTM KWIDEEGDPC TVSSQLEL
Highest antigen sequence identity to the following orthologs - mouse 95%, rat 95%.
Target Information
The PKC family of serine/threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-iota; PRKC-lambda/iota; Protein kinase C iota type; protein kinase C, iota
Gene Aliases: DXS1179E; nPKC-iota; PKCI; PRKCI
UniProt ID: (Human) P41743
Entrez Gene ID: (Human) 5584
protein phosphorylation
protein targeting to membrane
cytoskeleton organization
actin filament organization
positive regulation of neuron projection development
vesicle-mediated transport
cell migration
peptidyl-serine phosphorylation
cellular response to insulin stimulus
negative regulation of glial cell apoptotic process
establishment of apical/basal cell polarity
intracellular signal transduction
eye photoreceptor cell development
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
cell-cell junction organization
positive regulation of glucose import
secretion
Golgi vesicle budding
positive regulation of NF-kappaB transcription factor activity
positive regulation of glial cell proliferation
membrane organization
response to interleukin-1
bicellular tight junction assembly
positive regulation of establishment of protein localization to plasma membrane
positive regulation of endothelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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