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Invitrogen
FUT8 Polyclonal Antibody
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Product Details
PA5-65280
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human FUT8. Recombinant protein control fragment (Product #RP-104725).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTDLYYLSQTD GAGDWREKEA KDLTELVQRR ITYLQNPKDC SKAKKLVCNI NKGCGYGCQL HHVVYCFMIA YGTQRTLILE SQNWRYATGG WETVFRP
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.
Target Information
Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
Gene Aliases: FUT8
UniProt ID: (Human) Q9BYC5
Entrez Gene ID: (Human) 2530
in utero embryonic development
protein N-linked glycosylation
N-glycan processing
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
respiratory gaseous exchange
oligosaccharide biosynthetic process
regulation of gene expression
cell migration
protein N-linked glycosylation via asparagine
protein glycosylation in Golgi
N-glycan fucosylation
L-fucose catabolic process
receptor metabolic process
GDP-L-fucose metabolic process
regulation of cellular response to oxidative stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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