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Invitrogen
BTBD12 Polyclonal Antibody
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Product Details
PA5-65558
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human BTBD12. Recombinant protein control fragment (Product #RP-103627).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LIQYVNNEGFS AVEDGVLTQR VLLGDVSTEA ARTFLHYLYT ADTGLPPGLS SELSSLAHRF GVSELVHLCE QVPIATDSEG KPWEEKEAEN CESRA
Highest antigen sequence identity to the following orthologs - mouse 65%, rat 69%.
Target Information
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BTB/POZ domain-containing protein 12; Structure-specific endonuclease subunit SLX4
Gene Aliases: BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX4
UniProt ID: (Human) Q8IY92
Entrez Gene ID: (Human) 84464
resolution of meiotic recombination intermediates
double-strand break repair via homologous recombination
DNA replication
DNA repair
nucleotide-excision repair
DNA recombination
cellular response to DNA damage stimulus
DNA double-strand break processing involved in repair via single-strand annealing
positive regulation of telomere maintenance
telomeric D-loop disassembly
response to intra-S DNA damage checkpoint signaling
t-circle formation
negative regulation of telomere maintenance via telomere lengthening
positive regulation of t-circle formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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