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Invitrogen
PNAS4 Polyclonal Antibody
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Product Details
PA5-65589
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PNAS4. Recombinant protein control fragment (Product #RP-99772).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VVLNVYDMYWM NEYTSSIGIG VFHSGIEVYG REFAYGGHPY PFSGIFEISP GNASELGETF KFKEAVVLGS TDFLEDDIEK IVEELGKEY
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 99%.
Target Information
PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DeSI-2; desumoylating isopeptidase 1; Desumoylating isopeptidase 2; Deubiquitinase DESI2; family with sequence similarity 152, member A; Palmitoyl protein thioesterase DESI2; PPPDE peptidase domain-containing protein 1; Protein FAM152A; S-depalmitoylase DESI2
Gene Aliases: C1orf121; CGI-146; DESI; DeSI-2; DESI1; DESI2; FAM152A; PNAS-4; PPPDE1
UniProt ID: (Human) Q9BSY9
Entrez Gene ID: (Human) 51029
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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