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Invitrogen
RC74 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-65677
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human RC74. Recombinant protein control fragment (Product #RP-104929).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FAEWLCHNKQS KVYLPEPPFP HAELIQTNKL KHYPSIHGDF SNDFRQPCVV FTGHPSLRFG DVVHFMELWG KSSLNTVIFT EPDFSYLEAL AP
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 97%.
Target Information
INTS9 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A)and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1)and U2 (RNU2)(Baillat et al., 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Int9; Integrator complex subunit 9; Protein related to CPSF subunits of 74 kDa; RC-74; unnamed protein product
Gene Aliases: CPSF2L; INT9; INTS9; RC74
UniProt ID: (Human) Q9NV88
Entrez Gene ID: (Human) 55756
snRNA processing
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of transcription elongation from RNA polymerase II promoter
snRNA 3'-end processing
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
RNA polymerase II transcription initiation surveillance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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