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Invitrogen
RAMP2 Polyclonal Antibody
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Product Details
PA5-65695
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human RAMP2. Recombinant protein control fragment (Product #RP-106369).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PLPTTGTPGSE GGTVKNYETA VQFCWNHYKD QMDPIEKDWC DWAMISRPYS TLRDCLEHFA ELFDLGFPNP LAERIIFETH QIHFANCSLV QP
Highest antigen sequence identity to the following orthologs - mouse 55%, rat 56%.
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcitonin receptor-like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; RAMP2; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; Receptor activity-modifying protein 2; RP23-281C18.6; type I transmembrane protein
Gene Aliases: RAMP2
UniProt ID: (Human) O60895
Entrez Gene ID: (Human) 10266
angiogenesis
vasculogenesis
sprouting angiogenesis
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
regulation of blood pressure
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
protein transport
receptor internalization
cellular response to hormone stimulus
adherens junction assembly
cellular response to vascular endothelial growth factor stimulus
negative regulation of vascular permeability
positive regulation of angiogenesis
bicellular tight junction assembly
basement membrane assembly
protein localization to plasma membrane
vascular smooth muscle cell development
amylin receptor 2 signaling pathway
adrenomedullin receptor signaling pathway
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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