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Invitrogen
E4F1 Polyclonal Antibody
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Product Details
PA5-65697
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human E4F1. Recombinant protein control fragment (Product #RP-106370).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LEVEELLVSED SPAAATTVLT EDPHTVLVEF SSVVADTQEY IIEATADDAE TSEATEIIEG TQTEVDSHIM KVVQQIVHQA SAGHQIIVQN
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 93%.
Target Information
May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E4F transcription factor 1; p120E4F; p50E4F; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; Transcription factor E4F1
Gene Aliases: E4F; E4F1
UniProt ID: (Human) A8K2R4
Entrez Gene ID: (Human) 1877
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
ligase activity
cAMP response element binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription, DNA-templated
mitotic nuclear division
cell proliferation
regulation of mitotic cell cycle, embryonic
regulation of cell cycle process
viral process
protein ubiquitination
regulation of growth
cell division
mitotic cell cycle arrest
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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