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Invitrogen
TRIM27 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-65785
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human TRIM27. Recombinant protein control fragment (Product #RP-104964).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DIGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS DMEKIQELRE AQLYSVDV
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ret finger protein; RFP transforming protein; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; tripartite motif protein TRIM27; tripartite motif-containing protein 27; unnamed protein product
Gene Aliases: RFP; RNF76
UniProt ID: (Human) P14373
Entrez Gene ID: (Human) 5987
negative regulation of transcription from RNA polymerase II promoter
spermatogenesis
negative regulation of autophagy
regulation of tumor necrosis factor-mediated signaling pathway
protein ubiquitination
protein sumoylation
negative regulation of type I interferon production
negative regulation of viral transcription
Arp2/3 complex-mediated actin nucleation
retrograde transport, endosome to Golgi
negative regulation by host of viral release from host cell
innate immune response
negative regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
protein K63-linked ubiquitination
antiviral innate immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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