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Invitrogen
PALB2 Polyclonal Antibody
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FIGURE: 1 / 3
PALB2 Antibody (PA5-66053) in ICC/IF
Knockdown of Partner and localizer of BRCA2 was achieved by transfecting MCF7 cells with Partner and localizer of BRCA2 specific siRNA (Silencer® select Product # S527981, S36200). Immunofluorescence analysis was performed on untransfected MCF7 cells (panel a,d), transfected with non-specific scrambled siRNA (panels b,e) and transfected with Partner and localizer of BRCA2 specific siRNA (panel c,f). Cells were fixed, permeabilized, and labelled with PALB2 Polyclonal Antibody (Product # PA5-66053, at a concentration of 1 µg/mL) followed by ... View More
Product Details
PA5-66053
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PALB2. Recombinant protein control fragment (Product #RP-106745).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YDKLHIKTHLD EETGEKTSIT LDVGPESFNP GDGPGGLPIQ RTDDTQEHFP HRVSDPSGEQ KQKLPSRRKK QQKRTFISQE RDCVFGTDSL
Highest antigen sequence identity to the following orthologs - mouse 39%, rat 41%.
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ21816; Partner and localizer of BRCA2
Gene Aliases: FANCN; PALB2; PNCA3
UniProt ID: (Human) Q86YC2
Entrez Gene ID: (Human) 79728
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
somitogenesis
inner cell mass cell proliferation
mesoderm development
organ morphogenesis
chromosome breakage
multicellular organism growth
post-anal tail morphogenesis
negative regulation of apoptotic process
embryonic organ development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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