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Invitrogen
DNA2 Polyclonal Antibody
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Product Details
PA5-66086
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human DNA2. Recombinant protein control fragment (Product #RP-106781).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YLPSFCKWAGD FMHKNTSTDF PQMQLSLPSD NSKDNSTCNI EVVKPMDIEE SIWSPRFGLK GKIDVTVGVK IHRGYKTKYK IMPLELKTGK ESNSIEHRSQ
Highest antigen sequence identity to the following orthologs - mouse 82%, rat 82%.
Target Information
DNA2 is a conserved helicase/nuclease involved in themaintenance of mitochondrial and nuclear DNA stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2-like helicase; hDNA2
Gene Aliases: DNA2; DNA2L; hDNA2; KIAA0083
UniProt ID: (Human) P51530
Entrez Gene ID: (Human) 1763
DNA binding
DNA helicase activity
helicase activity
nuclease activity
protein binding
ATP binding
ATPase activity
site-specific endodeoxyribonuclease activity, specific for altered base
5'-flap endonuclease activity
5'-3' DNA helicase activity
single-stranded DNA-dependent ATPase activity
metal ion binding
4 iron, 4 sulfur cluster binding
DNA replication checkpoint
telomere maintenance via recombination
telomere maintenance
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
mitochondrial DNA replication
base-excision repair
DNA duplex unwinding
DNA replication, Okazaki fragment processing
DNA replication, removal of RNA primer
mitochondrial DNA repair
positive regulation of DNA replication
nucleic acid phosphodiester bond hydrolysis
regulation of signal transduction by p53 class mediator
mitotic telomere maintenance via semi-conservative replication
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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