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Invitrogen
SETD1B Polyclonal Antibody
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Product Details
PA5-66255
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SETD1B. Recombinant protein control fragment (Product #RP-106936).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GLQFVNLPPYR GPFSLSNSGP GRGQHWPPLP KFDPSVPPPG YMPRQEDPHK ATVDGVLLVV LKELKAIMK
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 97%.
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase SETD1B; hSET1B; Lysine N-methyltransferase 2G; SET domain-containing protein 1B
Gene Aliases: IDDSELD; KIAA1076; KMT2G; SET1B; SETD1B
UniProt ID: (Human) Q9UPS6
Entrez Gene ID: (Human) 23067
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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