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Invitrogen
PLA1A Polyclonal Antibody
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Product Details
PA5-66277
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PLA1A. Recombinant protein control fragment (Product #RP-106963).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QCQINQVKFKF QSSNRVWKKD RTTIIGKFCT ALLPVNDREK MVCLPEPVNL QASVTVSCDL KIAC
Highest antigen sequence identity to the following orthologs - mouse 71%, rat 68%.
Target Information
PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Phosphatidylserine-specific phospholipase A1; phosphatidylserine-specific phospholipase A1alpha; Phospholipase A1 member A; PS-PLA1; similar to the following EST sequences: GenBank Accession Numbers T96213 and T96131; 3'UTR nmd sequence found in U30998; unnamed protein product
Gene Aliases: NMD; PLA1A; PS-PLA1; PSPLA1
UniProt ID: (Human) Q53H76
Entrez Gene ID: (Human) 51365
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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