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Invitrogen
CRB1 Polyclonal Antibody
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Product Details
PA5-66373
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CRB1. Recombinant protein control fragment (Product #RP-107048).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LLLALENSTYQ YIRVWLERGR LAMLTPNSPK LVVKFVLNDG NVHLISLKIK PYKIELYQSS QNLGFISAST WKIEKGDV
Highest antigen sequence identity to the following orthologs - mouse 75%, rat 68%.
Target Information
CRB1 (Crumbs homolog 1) plays a role in photoreceptor morphogenesis in the retina. It may maintain cell polarization and adhesion. CRB1 is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. The first identified human homolog, CRB1, is expressed in retina and some parts of the brain, leaving room for another homolog to function in epithelial tissues. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: crumbs 1, cell polarity complex component; crumbs family member 1, photoreceptor morphogenesis associated; Crumbs homolog 1; Protein crumbs homolog 1; retina-specific; similar to Drosophila crumbs protein; similar to Drosophila CRUMBS protein; unnamed protein product
Gene Aliases: CRB1; CRB1-A; CRB1-B; CRB1-C; LCA8; RP12
UniProt ID: (Human) P82279
Entrez Gene ID: (Human) 23418
blood vessel remodeling
plasma membrane organization
cell communication
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
establishment or maintenance of cell polarity
cell-cell signaling
visual perception
protein localization
glial cell differentiation
gene expression
retina layer formation
signaling
photoreceptor cell outer segment organization
eye photoreceptor cell development
establishment or maintenance of epithelial cell apical/basal polarity
photoreceptor cell maintenance
detection of light stimulus involved in visual perception
retina development in camera-type eye
retina morphogenesis in camera-type eye
post-embryonic retina morphogenesis in camera-type eye
membrane organization
establishment of bipolar cell polarity involved in cell morphogenesis
cellular response to light stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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