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Invitrogen
FEM1A Polyclonal Antibody
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Product Details
PA5-66607
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human FEM1A. Recombinant protein control fragment (Product #RP-107265).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VEYLIQEQPGQ EQVAGGEAQP GLPQEDPSTS QGCAQPQGAP CCSSSPEEPL NGESYESCCP TSREAAVEA
Highest antigen sequence identity to the following orthologs - mouse 57%, rat 56%.
Target Information
FEM1A (FEM-1 homolog a), also known as EPRAP (Prostaglandin E receptor 4-associated protein), is a 669 amino acid cytoplasmic protein that belongs to the FEM-1 family. FEM1A is present in atheromata and in macrophages derived from peripheral blood monocytes. FEM1A may be a component of an E3 ubiquitin-protein ligase complex and functions as a substrate recognition subunit. It is suggested that FEM1A participates in anti-inflammatory signaling of macrophages via its interaction with EP4. FEM1A is down-regulated in Rhabdomyosarcoma, the most common soft tissue neoplasm of children. FEM1A is considered a candidate gene for polycystic ovary syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762M136; FEM1-alpha; FEM1a; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; unnamed protein product
Gene Aliases: EPRAP; FEM1A
UniProt ID: (Human) Q9BSK4
Entrez Gene ID: (Human) 55527
MAPK cascade
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of ubiquitin-protein transferase activity
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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