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Invitrogen
THRAP3 Polyclonal Antibody
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Product Details
PA5-66631
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human THRAP3. Recombinant protein control fragment (Product #RP-107285).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGKRSEGGHRG FVPEKNFRVT AYKAVQEKSS SPPPRKTSES RDKLGAKGDF PTGKSSFSIT REAQVNVRMD SFDEDLARPS GL
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 93%.
Target Information
THRAP3 is a 955 amino acid novel nuclear receptor and a member of the Thyroid hormone receptor associated proteins with a LISH domain and no obvious known sequence motifs. THRAP3 is a 150 kDa subunit of the large multiprotein complex TRAP and is important in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It is also known to play an important role in transcriptional coactivation. It is known to interact with DKC1, nop5/nap65 and fibrillarin. From the Northern blot analysis of several human tissues it was found that TRAP150 is ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCLAF1 and THRAP3 family member 2; Thyroid hormone receptor-associated protein 3; Thyroid hormone receptor-associated protein complex 150 kDa component; thyroid hormone receptor-associated protein, 150 kDa subunit; Trap150
Gene Aliases: BCLAF2; THRAP3; TRAP150
UniProt ID: (Human) Q9Y2W1
Entrez Gene ID: (Human) 9967
core promoter sequence-specific DNA binding
RNA polymerase II transcription cofactor activity
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
ATP binding
ligand-dependent nuclear receptor transcription coactivator activity
vitamin D receptor binding
poly(A) RNA binding
thyroid hormone receptor binding
phosphoprotein binding
nucleic acid metabolism protein
regulation of alternative mRNA splicing, via spliceosome
nuclear-transcribed mRNA catabolic process
transcription initiation from RNA polymerase II promoter
mRNA processing
circadian rhythm
RNA splicing
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
positive regulation of circadian rhythm
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mRNA splicing, via spliceosome
mRNA stabilization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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