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Invitrogen
LIMD1 Polyclonal Antibody
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Product Details
PA5-66671
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human LIMD1. Recombinant protein control fragment (Product #RP-105303).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDKYDDLGLEA SKFIEDLNMY EASKDGLFRV DKGAGNNPEF EETRRVFATK MAKIHLQQ
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 98%.
Target Information
The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6 and Zyxin. Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers. Limd1 blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIM domain-containing protein 1
Gene Aliases: LIMD1
UniProt ID: (Human) Q9UGP4
Entrez Gene ID: (Human) 8994
response to hypoxia
osteoblast development
transcription, DNA-templated
regulation of transcription, DNA-templated
cytoskeleton organization
signal transduction
multicellular organism development
regulation of cell shape
phosphorylation
cell migration
cytoplasmic mRNA processing body assembly
gene silencing by miRNA
negative regulation of hippo signaling
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
positive regulation of gene silencing by miRNA
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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