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Invitrogen
CLASP2 Polyclonal Antibody
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Product Details
PA5-66893
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CLASP2. Recombinant protein control fragment (Product #RP-107542).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LHNHLRNTGNG TQSSMGSPLT RPTPRSPANW SSPLTSPTN
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CLASP2-delta; CLASP2-epsilon; CLIP-associating protein 2; CLIP-associating protein CLASP2; Cytoplasmic linker-associated protein 2; hOrbit2; multiple asters (Mast)-like homolog 2; Protein Orbit homolog 2; unnamed protein product
Gene Aliases: CLASP2; KIAA0627
UniProt ID: (Human) O75122
Entrez Gene ID: (Human) 23122
microtubule cytoskeleton organization
vesicle targeting
microtubule nucleation
negative regulation of microtubule depolymerization
Golgi organization
mitotic spindle organization
establishment or maintenance of cell polarity
exit from mitosis
regulation of gastrulation
positive regulation of epithelial cell migration
regulation of epithelial to mesenchymal transition
regulation of axon extension
microtubule organizing center organization
regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
regulation of microtubule-based process
regulation of actin cytoskeleton organization
microtubule anchoring
platelet-derived growth factor receptor-beta signaling pathway
establishment of mitotic spindle localization
positive regulation of exocytosis
cell division
negative regulation of stress fiber assembly
regulation of focal adhesion assembly
negative regulation of focal adhesion assembly
basement membrane organization
positive regulation of extracellular matrix disassembly
mitotic spindle assembly
presynaptic cytoskeleton organization
negative regulation of wound healing, spreading of epidermal cells
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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