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Invitrogen
EPPK1 Polyclonal Antibody
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Product Details
PA5-66913
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human EPPK1. Recombinant protein control fragment (Product #RP-107564).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STGRFKGCSVS LWDLLLSEYV GADKRRELVA LCRSGRAAAL RQVVSAVTTL VEAAERQPLQ ATFRGLRKQV SARDLFRAQL ISRKTLDEL
Highest antigen sequence identity to the following orthologs - mouse 36%, rat 36%.
Target Information
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 450 kDa epidermal antigen; epidermal autoantigen 450K; Epiplakin
Gene Aliases: EPIPL; EPIPL1; EPPK1
UniProt ID: (Human) P58107
Entrez Gene ID: (Human) 83481
negative regulation of keratinocyte proliferation
negative regulation of cell migration
wound healing
intermediate filament cytoskeleton organization
intermediate filament organization
intermediate filament bundle assembly
negative regulation of epithelial cell proliferation
negative regulation of keratinocyte migration
negative regulation of wound healing
regulation of epithelium regeneration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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