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Invitrogen
DAB1 Polyclonal Antibody
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Product Details
PA5-66929
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human DAB1. Recombinant protein control fragment (Product #RP-105429).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSTETELQVAV KTSAKKDSRK KGQDRSEATL IKRFKGEGVR YKAKL
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; DAB1, reelin adaptor protein; Disabled homolog 1; RP23-356E21.1; spinocerebellar ataxia 37; unnamed protein product; yotari
Gene Aliases: DAB1; SCA37
UniProt ID: (Human) O75553
Entrez Gene ID: (Human) 1600
neuron migration
cell adhesion
negative regulation of cell adhesion
JAK-STAT cascade
small GTPase mediated signal transduction
nervous system development
axonogenesis
adult walking behavior
dendrite development
ventral spinal cord development
cerebellum structural organization
hippocampus development
cerebral cortex cell migration
cerebral cortex radially oriented cell migration
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
layer formation in cerebral cortex
radial glia guided migration of Purkinje cell
central nervous system neuron differentiation
cell differentiation
neuron differentiation
reelin-mediated signaling pathway
positive regulation of neuron differentiation
negative regulation of JAK-STAT cascade
astrocyte differentiation
negative regulation of astrocyte differentiation
negative regulation of axonogenesis
Golgi localization
regulation of synapse maturation
motor neuron migration
lateral motor column neuron migration
radial glia-guided pyramidal neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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