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Invitrogen
APOBEC3C Polyclonal Antibody
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Product Details
PA5-67178
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human APOBEC3C. Recombinant protein control fragment (Product #RP-107823).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NLWEANDRNET WLCFTVEGIK RRSVVS
Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 41%.
Target Information
APOBEC (apolipoprotein B mRNA editing enzyme, catalytic) proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A3C; APOBEC1-like; apolipoprotein B editing enzyme catalytic polypeptide-like 3C; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C; bK150C2.3; DNA dC->dU-editing enzyme APOBEC-3C; MGC19485; Phorbolin I; probable DNA dC->dU-editing enzyme APOBEC-3C; unnamed protein product
Gene Aliases: A3C; APOBEC1L; APOBEC3C; ARDC2; ARDC4; ARP5; bK150C2.3; PBI
UniProt ID: (Human) Q9NRW3
Entrez Gene ID: (Human) 27350
immune system process
negative regulation of transposition, RNA-mediated
negative regulation of macromolecule biosynthetic process
cytidine to uridine editing
hypomethylation of CpG island
clearance of foreign intracellular DNA
negative regulation of viral genome replication
innate immune response
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
defense response to virus
DNA cytosine deamination
defense response to symbiont
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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