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Invitrogen
MCM10 Polyclonal Antibody
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Product Details
PA5-67218
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human MCM10. Recombinant protein control fragment (Product #RP-105551).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: REKLEEIDWVT FGVILKKVTP QSVNSGKTFS IWKLNDLRDL TQCVSLFLFG EVHKALWKTE QGTVVGILNA NPMK
Highest antigen sequence identity to the following orthologs - mouse 84%, rat 88%.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of yeast MCM10; HsMCM10; MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance complex component 10; Protein MCM10 homolog; unnamed protein product
Gene Aliases: CNA43; DNA43; IMD80; MCM10; PRO2249
UniProt ID: (Human) Q7L590
Entrez Gene ID: (Human) 55388
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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