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Invitrogen
IkB zeta Polyclonal Antibody
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Product Details
PA5-67382
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human IkB zeta. Recombinant protein control fragment (Product #RP-108043).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CQPFQVRGSQQ MIDQASLYQY SPQNQHVEQQ PHYTHKPTLE YSPFPIPPQS PAYEPNLFDG PESQFCPNQS LVSLLGDQRE SENIANPM
Highest antigen sequence identity to the following orthologs - mouse 49%, rat 39%.
Target Information
I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ30225; FLJ34463; I-kappa-B-zeta; IkB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340; unnamed protein product
Gene Aliases: I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta; ikB-zeta; IKBZ; INAP; MAIL; NFKBIZ
UniProt ID: (Human) Q9BYH8
Entrez Gene ID: (Human) 64332
toll-like receptor signaling pathway
adaptive immune response
lymphocyte activation involved in immune response
plasma cell differentiation
T cell mediated immunity
chronic inflammatory response
chromatin organization
chromatin remodeling
transcription from RNA polymerase II promoter
inflammatory response
response to xenobiotic stimulus
gene expression
regulation of gene expression
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
keratinocyte differentiation
T cell differentiation
positive regulation of defense response
response to lipopolysaccharide
keratinocyte activation
response to cytokine
B cell proliferation
mRNA transcription from RNA polymerase II promoter
skin development
keratinocyte proliferation
T-helper 1 cell differentiation
isotype switching
positive regulation of transcription from RNA polymerase II promoter
spleen development
homeostasis of number of cells within a tissue
positive regulation of inflammatory response
regulation of immune response
defense response to Gram-negative bacterium
T cell receptor signaling pathway
B cell receptor signaling pathway
response to folic acid
establishment of skin barrier
transcription preinitiation complex assembly
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
cellular response to transforming growth factor beta stimulus
T-helper 17 cell differentiation
response to cisplatin
inflammatory response to wounding
execution phase of apoptosis
cellular response to interleukin-17
skin epidermis development
response to Gram-positive bacterium
epithelial cell apoptotic process
B cell receptor apoptotic signaling pathway
positive regulation of T-helper 17 cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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