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Invitrogen
APC2 Polyclonal Antibody
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Product Details
PA5-67486
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human APC2. Recombinant protein control fragment (Product #RP-98394).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GQLSLLGSDVD GPSLAKAPIS APFVHEGLGV AVGGFPASRH GSPSRSARVP PFNYVPSPMV VAATTDSAAE K
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 77%.
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenomatosis polyposis coli 2; adenomatous polyposis coli like; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like; APC2, WNT signaling pathway regulator; similar to APC1
Gene Aliases: APC2; APCL; MRT74
UniProt ID: (Human) O95996
Entrez Gene ID: (Human) 10297
microtubule cytoskeleton organization
cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
nervous system development
Wnt signaling pathway
cell migration
negative regulation of Wnt signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of canonical Wnt signaling pathway
activation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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