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Invitrogen
Cytokeratin 17 Polyclonal Antibody
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Product Details
PA5-81874
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KRT17. Recombinant protein control fragment (Product #RP-96642).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ARDYSQYYRT IEELQNKILT ATVDNANILL QIDNARLAAD DFRTKFETEQ ALRLSVEADI NGLRRVLDEL TLARADLEMQ IENLKEELAY LKKNHEEEMN ALRGQVGGEI NVEMDAAPGV DLSRI
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 94%.
Target Information
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between approximately40 kDa and approximately68 kDa and isoelectric pH between 4. 9 - 7. 8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39.1; CK-17; CK17; Cytokeratin-17; hard keratin; K17; keratin 17, type I; Keratin, type I cytoskeletal 17; Keratin-17; krt17 {ECO:0000250|UniProtKB:Q04695}; Type I keratin Ka17
Gene Aliases: 39.1; CK-17; K17; Ka17; KRT17; PC; PC2; PCHC1
UniProt ID: (Human) Q04695, (Rat) Q6IFU8
Entrez Gene ID: (Human) 3872, (Rat) 287702
signal transduction
epidermis development
positive regulation of cell growth
hair follicle morphogenesis
keratinization
intermediate filament organization
positive regulation of translation
positive regulation of hair follicle development
morphogenesis of an epithelium
intermediate filament-based process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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