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Invitrogen
MLLT11 Polyclonal Antibody
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Product Details
PA5-81879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MLLT11. Recombinant protein control fragment (Product #RP-93690).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FWRMPIPELD LSELEGLGLS DTATYKVKDS SVGKMIGQAT AADQEKNPEG DGLLEYSTFN FWRAPIASIH SFEL
Highest antigen sequence indentity to the following orthologs: Rat - 79%, Mouse - 83%.
Target Information
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AF1Q; ALL1 fused gene from chromosome 1q; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11; Protein AF1q; transmembrane protein; unnamed protein product
Gene Aliases: AF1Q; MLLT11
UniProt ID: (Human) Q13015
Entrez Gene ID: (Human) 10962
positive regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of mitochondrial depolarization
positive regulation of release of cytochrome c from mitochondria
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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