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Invitrogen
OASL Polyclonal Antibody
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FIGURE: 1 / 8
OASL Antibody (PA5-81946) in ICC/IF
Immunofluorescence analysis of 2'-5'-oligoadenylate synthase-like protein was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with OASL Polyclonal Antibody (Product # PA5-81946) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody... View More
Product Details
PA5-81946
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human OASL. Recombinant protein control fragment (Product #RP-99399).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EVLDAVRTVE EFLRQEHFQG KRGLDQDVRV LKVVKVGSFG NGTVLRSTRE VELVAFLSCF HSFQEAAKHH KDVLRLIWKT MWQSQDLLDL GLEDLRMEQR VPDALVFTIQ TRGTAEPITV TIVPAYRAL
Highest antigen sequence indentity to the following orthologs: Mouse - 70%, Rat - 72%.
Target Information
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; p59 OASL; p59OASL; Thyroid receptor-interacting protein 14; TR-interacting protein 14; unnamed protein product
Gene Aliases: OASL; OASL1; OASLd; p59 OASL; p59-OASL; p59OASL; TRIP-14; TRIP14
UniProt ID: (Human) Q15646
Entrez Gene ID: (Human) 8638
immune system process
response to virus
negative regulation of viral genome replication
innate immune response
defense response to virus
type I interferon signaling pathway
interleukin-27-mediated signaling pathway
defense response to other organism
antiviral innate immune response
positive regulation of RIG-I signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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