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Invitrogen
ECE1 Polyclonal Antibody
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Product Details
PA5-81948
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ECE1. Recombinant protein control fragment (Product #RP-99357).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IMDPKELDKV FNDYTAVPDL YFENAMRFFN FSWRVTADQL RKAPNRDQWS MTPPMVNAYY SPTKNEIVFP AGILQAPFYT RSSPKALNFG GIGVVVGHEL THAFDDQGRE YDKDGNLRPW WKNSSVEAFK R
Highest antigen sequence indentity to the following orthologs: Rat - 98%, Mouse - 98%.
Target Information
Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ECE 1; ECE-1; Endothelin-converting enzyme 1; unnamed protein product
Gene Aliases: ECE; ECE1
UniProt ID: (Human) P42892
Entrez Gene ID: (Human) 1889
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by endothelin
proteolysis
signal transduction
G-protein coupled receptor signaling pathway
axon guidance
heart development
anatomical structure morphogenesis
gene expression
substance P catabolic process
bradykinin catabolic process
calcitonin catabolic process
protein processing
peptide hormone processing
regulation of vasoconstriction
neuron projection development
endothelin maturation
embryonic heart tube development
hormone catabolic process
embryonic digit morphogenesis
ear development
pharyngeal system development
axonogenesis involved in innervation
sympathetic neuron axon guidance
semaphorin-plexin signaling pathway involved in axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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