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Invitrogen
FIBB Polyclonal Antibody
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Product Details
PA5-81988
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FGB. Recombinant protein control fragment (Product #RP-100424).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ERKAPDAGGC LHADPDLGVL CPTGCQLQEA LLQQERPIRN SVDELNNNVE AVSQTSSSSF QYMYLLKDLW QKRQKQVKDN ENVVNEYSSE LEKHQLYIDE TVNSNIPTNL RVLRSILENL RSKIQKLE
Highest antigen sequence indentity to the following orthologs: Mouse - 74%, Rat - 73%.
Target Information
FIBB is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-fibrinogen; beta-fibrinogen precursor; epididymis secretory sperm binding protein Li 78p; Fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405; unnamed protein product
Gene Aliases: FGB; HEL-S-78p
UniProt ID: (Human) P02675
Entrez Gene ID: (Human) 2244
adaptive immune response
immune system process
cell-matrix adhesion
blood coagulation
hemostasis
platelet activation
plasminogen activation
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
induction of bacterial agglutination
cellular response to leptin stimulus
innate immune response
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
protein polymerization
response to calcium ion
protein-containing complex assembly
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
cellular response to interleukin-1
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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