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Invitrogen
IRF4 Polyclonal Antibody
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FIGURE: 1 / 7
IRF4 Antibody (PA5-81999) in IHC (P)
Immunohistochemistry analysis of IRF4 in human duodenum, kidney, pancreas and tonsil. Samples were incubated with IRF4 polyclonal antibody (Product # PA5-81999). Shows similar protein distribution across tissues to independent IRF4 antibody (Product # PA5-82031) (B).
Product Details
PA5-81999
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Horse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human IRF4. Recombinant protein control fragment (Product #RP-101886).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SNDFEELVER SQLDISDPYK VYRIVPEGAK KGAKQLTLED PQMSMSHPYT MTTPYPSLPA QQVHNYMMPP LDRSWRDYVP DQPHPEIPYQ CPMTFGPRGH HWQGPACENG CQVTGTFYAC APPE
Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Interferon regulatory factor 4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; NF-EM5
Gene Aliases: IMD131; IRF4; LSIRF; MUM1; NF-EM5; SHEP8
UniProt ID: (Human) Q15306
Entrez Gene ID: (Human) 3662
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
immune system process
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of interleukin-10 production
positive regulation of interleukin-13 production
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
negative regulation of toll-like receptor signaling pathway
T cell activation
defense response to protozoan
myeloid dendritic cell differentiation
regulation of T-helper cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of multicellular organismal process
T-helper 17 cell lineage commitment
positive regulation of cold-induced thermogenesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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