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Invitrogen

BNIP3 Polyclonal Antibody

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Product Details

PA5-82053

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human BNIP3. Recombinant protein control fragment (Product #RP-88893).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789214

Product Specific Information

Immunogen sequence: MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKG

Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 89%.

Target Information

NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B interacting protein 3; BNIP3; Hypoxia-Activated BNIP3 Overlapping Non-coding RNA; lacks exon 2; BNIP3deltaExon2; nineteen kD interacting protein-3; pro-apoptotic mitochondrial protein; unnamed protein product

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Gene Aliases: BNIP3; HABON; NIP3

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UniProt ID: (Human) Q12983

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Entrez Gene ID: (Human) 664

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Function(s)
protein binding identical protein binding protein homodimerization activity GTPase binding endoplasmic reticulum-autophagosome adaptor activity mitochondrion autophagosome adaptor activity
Process(es)
mitophagy mitophagy response to hypoxia apoptotic process response to bacterium positive regulation of autophagy negative regulation of mitochondrial fusion cardiac muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process negative regulation of mitochondrial membrane potential positive regulation of macroautophagy cerebral cortex development mitochondrial protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of programmed cell death positive regulation of protein complex disassembly mitochondrial fragmentation involved in apoptotic process negative regulation of membrane potential regulation of mitochondrial membrane permeability autophagic cell death response to axon injury oligodendrocyte differentiation brown fat cell differentiation neuron apoptotic process positive regulation of mitochondrial calcium ion concentration defense response to virus response to hyperoxia reticulophagy substrate localization to autophagosome cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to cobalt ion cellular response to hypoxia reactive oxygen species metabolic process positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria response to oxygen-glucose deprivation intrinsic apoptotic signaling pathway mitochondrial outer membrane permeabilization granzyme-mediated programmed cell death signaling pathway negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitophagy intrinsic apoptotic signaling pathway in response to hypoxia
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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