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Invitrogen
TCP-1 beta Polyclonal Antibody
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FIGURE: 1 / 8
TCP-1 beta Antibody (PA5-82068) in IHC (P)
Immunohistochemistry analysis of TCP-1 beta in human cerebral cortex, skeletal muscle, testis and tonsil. Samples were incubated with TCP-1 beta polyclonal antibody (Product # PA5-82068). Shows similar protein distribution across tissues to independent TCP-1 beta antibody (Product # PA5-82069) (B).
Product Details
PA5-82068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCT2. Recombinant protein control fragment (Product #RP-96783).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DALCVLAQTV KDSRTVYGGG CSEMLMAHAV TQLANRTPGK EAVAMESYAK ALRMLPTIIA DNAGYDSADL VAQLRAAHSE GNTTAGLDMR EGTIGDMAIL GITESFQVKR QVLLSAAEAA EVILRVDN
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 95%.
Target Information
TCP-1 beta is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). The CCT complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the TCP-1 beta gene have been observed but not thoroughly characterized. A disease associated with TCP-1 beta protein dysfunction include epididymo-orchitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI528772; c-cpn; CCT; CCT-beta; Cct1; Ccta; Chaperonin containing T-complex polypeptide 1 subunit 2; chaperonin containing t-complex polypeptide 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing TCP1, subunit 2 (beta); chaperonin subunit 2 (beta); epididymis secretory sperm binding protein Li 100n; p63; T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; Tcp-1; TCP-1-beta; Tp63; TRic
Gene Aliases: 99D8.1; CCT-beta; CCT2; CCTB; HEL-S-100n; PRO1633; TCP-1-beta
UniProt ID: (Human) P78371, (Mouse) P80314, (Rat) Q5XIM9
Entrez Gene ID: (Human) 10576, (Mouse) 12461, (Rat) 299809
protein folding
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomerase
protein stabilization
chaperone mediated protein folding independent of cofactor
chaperone-mediated protein complex assembly
positive regulation of telomerase activity
scaRNA localization to Cajal body
toxin transport
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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