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Invitrogen
MKP4 Polyclonal Antibody
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Product Details
PA5-82081
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DUSP9. Recombinant protein control fragment (Product #RP-92206).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ECPHLCETSL AGRAGSSMAP VPGPVPVVGL GSLCLGSDCS DAESEADRDS MSCGLDSEGA TPPPVGLRAS FPVQILPNLY LGSARDSANL ESLAKLGIRY ILNVTPNLPN FFEKNGDFHY KQI
Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 80%.
Target Information
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X and MKP-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 9; MAP kinase phosphatase 4; Mitogen-activated protein kinase phosphatase 4; serine/threonine specific protein phosphatase; unnamed protein product
Gene Aliases: DUSP9; MKP-4; MKP4
UniProt ID: (Human) Q99956
Entrez Gene ID: (Human) 1852
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
hydrolase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
MAP kinase tyrosine phosphatase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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