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Invitrogen
BAP31 Polyclonal Antibody
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Product Details
PA5-82124
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BCAP31. Recombinant protein control fragment (Product #RP-92343).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ESASEAAKKY MEENDQLKKG AAVDGGKLDV GNAEVKLEEE NRSLKADLQK LKDELASTKQ KLEKAENQVL AMRKQSEGLT KEYDRLLEEH AKLQAAVDGP
Highest antigen sequence indentity to the following orthologs: Rat - 84%, Mouse - 85%.
Target Information
BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 6C6 antigen; 6C6-AG tumor-associated antigen; accessory protein BAP31; B-cell receptor-associated protein 31; BCR-associated protein 31; BCR-associated protein Bap31; CDM protein; OTTHUMP00000025978; p28; p28 Bap31; Protein CDM; unnamed protein product
Gene Aliases: 6C6-AG; BAP31; BCAP31; CDM; DDCH; DELXQ28; DXS1357E; MICRODELXq28
UniProt ID: (Human) P51572, (Mouse) Q61335
Entrez Gene ID: (Human) 10134, (Rat) 293852, (Mouse) 27061
protein targeting to mitochondrion
intracellular protein transport
ER to Golgi vesicle-mediated transport
apoptotic process
spermatogenesis
protein transport
vesicle-mediated transport
response to endoplasmic reticulum stress
protein localization to endoplasmic reticulum exit site
positive regulation of retrograde protein transport, ER to cytosol
positive regulation of ERAD pathway
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
immune response
positive regulation of cytosolic calcium ion concentration
biological_process
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of mitochondrial calcium ion concentration
transport
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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