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Invitrogen
BIN1 Polyclonal Antibody
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Product Details
PA5-82188
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BIN1. Recombinant protein control fragment (Product #RP-89206).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VTAGKIASNV QKKLTRAQEK VLQKLGKADE TKDEQFEQCV QNFNKQLTEG TRLQKDLRTY LASVKAMHEA SKKLNECLQE VYEPDWPGRD EANKIAENND LLWMDYHQKL VDQALLTMDT YLGQFPDIKS RIAKRGRKLV DYDSARHH
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMPH 2; amphiphysin 2; amphiphysin I homolog; Amphiphysin II; amphiphysin isoform II; subtype 2; amphiphysin-like; Amphiphysin-like protein; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; Myc box-dependent-interacting protein 1; unnamed protein product
Gene Aliases: AMPH2; AMPHL; BIN1; CNM2; SH3P9
UniProt ID: (Human) O00297
Entrez Gene ID: (Human) 274
negative regulation of transcription from RNA polymerase II promoter
endocytosis
nucleus organization
cytoskeleton organization
endosome to lysosome transport
regulation of cell cycle process
regulation of endocytosis
cell differentiation
positive regulation of actin filament polymerization
T-tubule organization
positive regulation of apoptotic process
regulation of neuron differentiation
positive regulation of endocytosis
synaptic vesicle endocytosis
positive regulation of astrocyte differentiation
establishment of localization in cell
lipid tube assembly
regulation of heart rate by cardiac conduction
negative regulation of potassium ion transmembrane transport
negative regulation of beta-amyloid formation
negative regulation of ventricular cardiac muscle cell action potential
negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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