Search
Invitrogen
Blooms Syndrome Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-82207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BLM. Recombinant protein control fragment (Product #RP-95410).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STLKDLDTSD RKEDVLSTSK DLLSKPEKMS MQELNPETST DCDARQISLQ QQLIHVMEHI CKLIDTIPDD KLKLLDCGNE LLQQRNIRRK LLTEVDFNKS DASLLGSLWR YRPDSLDGPM EGDSCPTGNS MKELNFSHLP SNSV
Highest antigen sequence indentity to the following orthologs: Rat - 64%, Mouse - 64%.
Target Information
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Bloom syndrome protein; Bloom syndrome RecQ like helicase; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; DNA helicase, RecQ-like type 2; MGC126616; MGC131618; MGC131620; RecQ protein-like 3; RecQ-like DNA helicase BLM; RecQ2; unnamed protein product
Gene Aliases: BLM; BS; MGRISCE1; RECQ2; RECQL2; RECQL3
UniProt ID: (Human) P54132
Entrez Gene ID: (Human) 641
nucleotide binding
four-way junction DNA binding
Y-form DNA binding
bubble DNA binding
p53 binding
nucleic acid binding
DNA binding
DNA helicase activity
single-stranded DNA binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
zinc ion binding
four-way junction helicase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
isomerase activity
ATPase activity
identical protein binding
protein homodimerization activity
3'-5' DNA helicase activity
metal ion binding
G-quadruplex DNA binding
forked DNA-dependent helicase activity
telomeric D-loop binding
telomeric G-quadruplex DNA binding
8-hydroxy-2'-deoxyguanosine DNA binding
DNA/DNA annealing activity
regulation of cyclin-dependent protein serine/threonine kinase activity
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA replication
DNA repair
DNA recombination
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to X-ray
replication fork processing
telomere maintenance via semi-conservative replication
DNA geometric change
positive regulation of transcription, DNA-templated
negative regulation of DNA recombination
protein oligomerization
protein homooligomerization
negative regulation of cell division
telomeric D-loop disassembly
resolution of recombination intermediates
cellular response to ionizing radiation
cellular response to hydroxyurea
cellular response to camptothecin
t-circle formation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support