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Invitrogen
UBF-1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82245
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UBTF. Recombinant protein control fragment (Product #RP-89322).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: WKLLSQKEKD AYHKKCDQKK KDYEVELLRF LESLPEEEQQ RVLGEEKMLN INKKQATSPA SKKPAQEGGK GGSEKPKRPV SAMFIFSEEK RRQLQEERPE LSESELTRLL ARMWNDLSEK KK
Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
UBF-1 encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90-kDa nucleolus organizer region autoantigen; autoantigen NOR-90; NOR90; transcription factor UBF; unnamed protein product; upstream binding transcription factor, RNA polymerase I; upstream-binding factor 1
Gene Aliases: A930005G04Rik; CONDBA; NOR-90; Tcfubf; UBF; UBF-1; UBF1; UBF2
UniProt ID: (Human) P17480
Entrez Gene ID: (Human) 7343, (Mouse) 21429
RNA polymerase I preinitiation complex assembly
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase I promoter
regulation of glucose mediated signaling pathway
chromatin silencing at rDNA
transcription elongation from RNA polymerase I promoter
cellular response to leukemia inhibitory factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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