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Invitrogen
cGKI Polyclonal Antibody
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Product Details
PA5-82310
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRKG1. Recombinant protein control fragment (Product #RP-89820).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LADVLEETHY ENGEYIIRQG ARGDTFFIIS KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEA
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 42%.
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGK 1; cGK cGK cGKI; cGK cGK1; cGKI; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; RP11-346D6.1
Gene Aliases: AAT8; cGK; cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; PKG; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Human) Q13976
Entrez Gene ID: (Human) 5592
neuron migration
protein phosphorylation
signal transduction
dendrite development
cGMP-mediated signaling
actin cytoskeleton organization
forebrain development
regulation of GTPase activity
relaxation of vascular smooth muscle
negative regulation of platelet aggregation
mitophagy in response to mitochondrial depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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