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Invitrogen
LDLR Polyclonal Antibody
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Product Details
PA5-82385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LDLR. Recombinant protein control fragment (Product #RP-90205).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RTTLSNGGCQ YLCLPAPQIN PHSPKFTCAC PDGMLLARDM RSCLTEAEAA VATQETSTVR LKVSSTAVRT QHTTTRPVPD TSRLPGATPG LTTVEIVTMS HQALGDVAGR GNEKKPSSV
Highest antigen sequence indentity to the following orthologs: Mouse - 62%, Rat - 50%.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3; unnamed protein product
Gene Aliases: FH; FHC; FHCL1; LDLCQ2; LDLR
UniProt ID: (Human) P01130
Entrez Gene ID: (Human) 3949
beta-amyloid binding
virus receptor activity
protease binding
low-density lipoprotein receptor activity
calcium ion binding
protein binding
low-density lipoprotein particle binding
very-low-density lipoprotein particle receptor activity
clathrin heavy chain binding
identical protein binding
binding, bridging
lipoprotein particle binding
retinoid metabolic process
negative regulation of receptor recycling
lipid metabolic process
lipid transport
endocytosis
receptor-mediated endocytosis
phagocytosis
long-term memory
steroid metabolic process
cholesterol metabolic process
negative regulation of macromolecule metabolic process
positive regulation of gene expression
negative regulation of gene expression
positive regulation of triglyceride biosynthetic process
regulation of phosphatidylcholine catabolic process
negative regulation of low-density lipoprotein particle clearance
phospholipid transport
intestinal cholesterol absorption
cholesterol transport
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein catabolic process
cholesterol homeostasis
viral entry into host cell
artery morphogenesis
positive regulation of inflammatory response
negative regulation of multicellular organismal process
regulation of protein metabolic process
negative regulation of protein metabolic process
establishment of localization in cell
artery development
response to caloric restriction
negative regulation of astrocyte activation
cholesterol import
cellular response to fatty acid
cellular response to low-density lipoprotein particle stimulus
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
regulation of cholesterol metabolic process
beta-amyloid clearance
amyloid-beta clearance by cellular catabolic process
negative regulation of microglial cell activation
positive regulation of lysosomal protein catabolic process
negative regulation of amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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