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Invitrogen
PTP1B Polyclonal Antibody
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Product Details
PA5-82462
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTPN1. Recombinant protein control fragment (Product #RP-90585).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RFSYLAVIEG AKFIMGDSSV QDQWKELSHE DLEPPPEHIP PPPRPPKRIL EPHNGKCREF FPNHQWVKEE TQEDKDCPIK EEKGSPLNAA PYGIESMSQD TEVRSRVVGG SLRGAQAASP AKGEPSLPEK DEDHALSYW
Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 64%.
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CPTP1; EC 3.1.3.48; hgnc9642; KIAA0283; phosphotyrosyl-protein phosphatase (EC 3.1.3.48); protein tyrosine phosphatase, placental; Protein-tyrosine phosphatase 1B; PTN1; PTP-1B; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1; unnamed protein product
Gene Aliases: PTP1B; PTPN1
UniProt ID: (Human) P18031
Entrez Gene ID: (Human) 5770
RNA binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
insulin receptor binding
protein binding
zinc ion binding
hydrolase activity
phosphatase activity
enzyme binding
protein kinase binding
receptor tyrosine kinase binding
cadherin binding
ephrin receptor binding
protein phosphatase 2A binding
positive regulation of systemic arterial blood pressure
protein dephosphorylation
negative regulation of cell proliferation
insulin receptor signaling pathway
regulation of signal transduction
negative regulation of signal transduction
positive regulation of heart rate
positive regulation of cardiac muscle cell apoptotic process
negative regulation of cell-substrate adhesion
negative regulation of neuron projection development
actin cytoskeleton organization
regulation of endocytosis
regulation of proteolysis
negative regulation of vascular endothelial growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
response to nutrient levels
cellular response to insulin stimulus
regulation of intracellular protein transport
cellular response to unfolded protein
response to endoplasmic reticulum stress
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor-beta signaling pathway
cellular response to platelet-derived growth factor stimulus
IRE1-mediated unfolded protein response
insulin receptor recycling
negative regulation of MAP kinase activity
cellular response to fibroblast growth factor stimulus
positive regulation of JNK cascade
regulation of insulin receptor signaling pathway
negative regulation of insulin receptor signaling pathway
negative regulation of protein kinase B signaling
regulation of type I interferon-mediated signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to hypoxia
cellular response to nitric oxide
vascular endothelial cell response to oscillatory fluid shear stress
regulation of postsynapse assembly
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of IRE1-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response
cellular response to angiotensin
negative regulation of vascular associated smooth muscle cell migration
cellular response to nerve growth factor stimulus
response to angiotensin
positive regulation of endothelial cell apoptotic process
positive regulation of receptor catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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